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Destiny isn't a time traveler, and he doesn't use his book to alter what's already happened.
The worst he could probably do to Paul is stripping away all of his powers and abilities like he once did with Superman.
Or I suppose he could alter the Destiny's of everyone Paul cares about so they...
Mr Zoat has written out most of the higher level stuff in the setting so there's no real way to answer that.
Outside of this story however, all we really know is that Life and Anti-Life predate the Endless.
Faulty logic.
As you were unable to break into the Atlantis bubble through any manner you would thus be unable to break out of a similar bubble if you were stuck in one.