A potential fun idea for a story is someone getting The Gamer powers in a World of Darkness setting (can be an OC native from the setting, or some Insert character), which is especially fun if it follows the canon of The Gamer where the powers are bestowed by Gaia, who is a pretty big background figure in the WoD setting (mostly in Werewolf).
All of the WoD Changing Breeds were each created to aid Gaia with some specific a specific purpose, including all of the Werewolves in the setting, who are Gaia's warriors.
A possible thematic explenation is that the Gamer powers represent evolution, as The Gamer power is an adaptive ability, so powers grow, improve and adapt to whatever challenge the user faces as long as they survive.
Anything that worked against them once will not be as effective the second time around, especially when with The gamer gaining Resitances against any and all possible damage types, and improves both physically and mentally more and more over time.
The magic they use could be a lot more similar to the magic used in the WoD setting, but that would still include summoning a whole bunch of stuff or making pacts with spirits or elementals, just like in The Gamer webcomic (the spirits especially are closely tied to the Werewolves of the setting, so a lot can be done with them).
What kind of magic they learn also depends on from who they can learn and what they encounter, so unless they encounter some actual Awakened Mages, they're not going to be overpowered spellcasters early on, but that might be interesting to learn, ally, or fight them later on (and Mages or the Technocrasy can individually be any one of those).
Something that could be an interesting addicion is removing the actual dungeon creatons where hey train and grind their levels, so they actually have to fight against actual monsters such as vampires to grow in power, which adds a lot more risk.
Some other supernatural groups that it might be interesting for them to interact or fight with are:
- The Vampires (mostly just to fight)
- The Fae and Changelings (they're very interesting and often require a lot more intelligence and creative thinking than just directly fighting them because they're so crazy powerful)
- The Princesses from Princess: The Hopeful (one of the very few factions who's trying to improve the WoD world and prevent it from becoming so too bleak to care about anymore)
- Mummies (they're the other faction that's pretty much fully good, though working together with them is really difficult as they can only be awake for a very limited amount of time and only to accomplish missions for the Judge they serve)
- And of course, the Hunters (possibly as a faction they first ally with against other supernatural predators to get to know the ropes before moving on to stronger monsers, and the possibliity to interact with the cast of Hunter: The Parenting is also fantastic).
