Stsword
Versed in the lewd.
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Gaiman has gone on record saying he doesn't like how most other DC writers portray the Endless so most writers/creators leave them alone and as a result, they aren't really shown outside of the Sandman series or whatever else Gaiman writes about them. To answer your question they could be but they are mostly their own thing unconnected to the rest of the DC universe.
Literally, the Flashpoint event ended with the Vertigo universe merging with New Earth and Wildstorm, which would not be possible if Vertigo and New Earth were the same universe in the first place.